Agitation in RTT is largely a consequence of unrestrained sympathetic activity. Typical symptoms and behaviour include very short attention span, increased physical activity, dilated pupils, excessive perspiration and transpiration, sudden screams or rage. Management must include identification of the trigger event or situation. Treatment must start with the avoidance or removal of the likely trigger.
Eventual use of time-out in sensory deprivation is reasonable. The drugs of choice are Risperidone or Pipamperon by mouth in low doses administered twice daily.